Therapeutic targeting of 3′,5′-cyclic nucleotide phosphodiesterases: inhibition and beyond
نویسندگان
چکیده
منابع مشابه
Cyclic Nucleotide Phosphodiesterases and Thyroid Hormones*
Evidence is presented that modulation of the maximum velocity of a particulate low K,,, cyclic adenosine 3’:5’-monophosphate (cyclic AMP) phosphodiesterase by thyroid hormones is one mechanism for the regulation of the responsiveness of rat epididymal adipocytes to lipolytic agents such as epinephrine and glucagon. Fat cells of propylthiouracil-induced hypothyroid rats are unresponsive to lipol...
متن کاملCyclic nucleotide phosphodiesterases and thyroid hormones.
Evidence is presented that modulation of the maximum velocity of a particulate low K-m cyclic adenosine 3':5'-monophosphate (cyclic AMP) phosphodiesterase by thyroid hormones is one mechanism for the regulation of the responsiveness of rat epididymal adipocytes to lipolytic agents such as epinephrine and glucagon. Fat cells of propylthiouracil-induced hypothyroid rats are unresponsive to lipoly...
متن کاملCyclic nucleotide phosphodiesterases: relating structure and function.
Cyclic nucleotide phosphodiesterases (PDEs) comprise a superfamily of metallophosphohydrolases that specifically cleave the 3',5'-cyclic phosphate moiety of cAMP and/or cGMP to produce the corresponding 5'-nucleotide. PDEs are critical determinants for modulation of cellular levels of cAMP and/or cGMP by many stimuli. Eleven families of PDEs with varying selectivities for cAMP or cGMP have been...
متن کاملThe biology of cyclic nucleotide phosphodiesterases.
Of course, from childhood to forever, we are always thought to love reading. It is not only reading the lesson book but also reading everything good is the choice of getting new inspirations. Religion, sciences, politics, social, literature, and fictions will enrich you for not only one aspect. Having more aspects to know and understand will lead you become someone more precious. Yea, becoming ...
متن کاملCyclic nucleotide phosphodiesterases – 40 years of progress
In this lecture I will discuss some of the relevant history of cGMP-selective and cGMP-regulated phosphodiesterases. Emphasis will be put largely on those experiments carried out in our own laboratories over the last 40 years. Short vignettes or anecdotes on the discoveries of the "cGMPstimulated" (PDE2s) and "cGMP-inhibited" (PDE3s) phosphodiesterases as well as on the original cloning of PDEs...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2019
ISSN: 1474-1776,1474-1784
DOI: 10.1038/s41573-019-0033-4